If you're experiencing die-off reactions from herbal protocols, follow this guide. All steps can help prevent or treat symptoms like fatigue, joint pain, skin issues, brain fog, or digestive problems. The goal is to gradually increase dosing without compromising your quality of life.
π If you're not stable within 1β2 weeks, schedule a consult with the office.
β οΈ General Guidelines
Do not reintroduce new foods while taking GI-clearing herbs until you're symptom-free for 1β2 weeks.
If on a low-FODMAP diet, reintroduce moderate FODMAPs first, then high-FODMAPs.
If not on a low-FODMAP plan, focus on AIP foods first (see Food Reintroduction Handout).
π Signs of Die-Off:
Fatigue
Malaise
Achiness
Brain fog
Skin issues
GI distress
π Supplement Dosing Strategy
Sensitive patients: increase by 1 capsule per day.
Less sensitive: increase by 2β3 capsules per day if no symptoms occur.
Split doses throughout the day with food (breakfast/lunch/dinner).
If very sensitive, start with 1/4 or 1/2 capsule, mix with water or food.
Take herbs with food initially; switch to empty stomach dosing (10β30 min before meals) as tolerated.
πΊ Working Through Your Protocol
Only move to the next supplement after reaching full dose (usually 6 caps) or your maximum tolerated dose (<6).
Continue taking previously tolerated supplements as you add new ones.
Once you're stable for 1 week, you may try increasing your current doses weekly to reach the full protocol dose.
πͺ Stair Step Protocol (For Sensitive Patients)
Use same structure as above but aim for 3 caps max per supplement initially.
After all GI-clearing supplements reach 3 caps, stabilize for 1 week.
Then work up toward 6 caps total gradually if well-tolerated.
Example Week (Stair Step):
Mon: GI Clear 1 β 1 cap at breakfast
Tue: GI Clear 1 β 1 cap at breakfast + dinner
Wed: GI Clear 1 β 1 cap at all meals (max dose 3/day)
ThuβSat: Add GI Clear 2 using same steps
SunβTue: Add GI Clear 4 using same steps
π₯ Still Having Reactions?
Take a 3β7 day supplement holiday to return to baseline.
Reintroduce each supplement one at a time, 1 cap per day total (not per meal).
If symptoms return, drop to the last tolerated dose and stabilize before continuing.
Once stable on digestive/adrenal programs, add GI clearing protocol last.
Add Dr. Jβs GI Binder (charcoal, zeolite, chlorella) to support detox.
Take at bedtime and/or morning, away from food/supplements.
π§ Additional Die-Off Support
Binders: Charcoal, bentonite clay, diatomaceous earth, plant fibers (away from meals)
Be sure your bowels are moving consistently
Use Ginger Tea (recipe below) to reduce inflammation & improve detox
π΅ Ginger Tea Recipe
Ingredients:
3β4 thumb-sized pieces of fresh ginger, juiced or grated
(Or use organic ginger juice concentrate)
12β16 oz of hot water
1/4 cup ginger juice or tea
1/3 tsp to 1 tbsp Manuka honey (MGO 400+ recommended; optional)
Juice of 1/2 lime or lemon (optional)
1/8 tsp cayenne pepper (optional)
Instructions:
Combine ingredients in a large mug.
Stir well.
Sip throughout the day (do not drink all at once).
π‘ If sugar-sensitive, start with 1 tsp of honey. Honey and cayenne are optional if sensitive.
β
Summary
Follow dosing slowly and methodically.
Take time to stabilize before increasing doses.
Support detox with binders and ginger tea.
Reach out for help if symptoms persist.
Click here to schedule a consult if needed.